Modules/Publications

Within the PragMeta database, we collect and share data from published randomized trials that either have a specific design feature or other characteristic related to pragmatism or they form clusters of trials addressing the same research question but having different aspects of pragmatism. This lays the foundation to determine the relationship of various features of pragmatism, generalizability, and applicability with intervention effects or other trial characteristics.

The PragMeta database contains trial data actively collected for PragMeta, but also allows to import and link existing datasets of trials collected for other purposes, forming a large-scale meta-database.

PragMeta rationale and design peer-reviewed publication: doi 10.1186/s13063-023-07474-y
PragMeta protocol and procedures: Open Science Framework

We are working on multiple modules that feed the PragMeta database. The focus of each module is outlined below and publications are listed, if applicable.

PragCOVID: Overview of COVID-19 randomized trials self-labeled as pragmatic. Date of last search: February 21, 2022.

PragEpi: Overview of systematic reviews assessing included randomized trials using PRECIS-2. Details are provided on Open Science Framework. Date of last search: July 6, 2022.

PragMS: Overview of pragmatic randomized trials in multiple sclerosis. Details are provided on Open Science Framework and the related publication of findings. Date of last search: December 1, 2022.

PragQoL: Impact of pragmatism on the assessment of patient-reported outcomes compared with objective clinical outcomes. Details are provided on Open Science Framework. Date of last search: July 27, 2022.

PragRCD: Assessment and impact of pragmatism of randomized trials using routinely collected data for outcome assessment and traditional trials on treatment effects using a subset of https://doi.org/10.1136/bmj.n450.

PragRegistry: Assessment of pragmatism of randomized trials that reported at least one outcome derived from a registry using a subset of https://doi.org/10.1016/j.jclinepi.2024.111614.

We imported the following existing datasets of trials collected for other purposes, provided courtesy of the corresponding authors:

PragAntitumor: PRECIS-2 assessment in antineoplastic treatments. Original data from 10.1186/s12874-023-01975-9.

PragSurgery: PRECIS-2 assessment in surgery trials. Original data from 10.1001/jamanetworkopen.2021.14494.